What anti-malware programs should I use to keep my PC running efficiently? By YL ComputingSpeed Up PC The best anti-malware programs to use to keep your PC running efficiently are Windows Defender, Malwarebytes Premium, Bitdefender, Avast, and Kaspersky. Related Content:How can I clean up and optimize my hard disk for better performance?What anti-virus or security measures should I take to protect my PC from viruses and malware?What tips can I use to reduce load times on my computer?