How often should I defragment my hard drive to optimize performance? By YL ComputingDecember 6, 2022Speed Up PC It depends on how heavily you use your computer. If you use it often and have file-heavy applications installed, you should consider defragging your drive at least once per month. Otherwise, defragging once every three to four months will suffice. Related Content:Can I uninstall unnecessary programs to free up space on my computer?How can I make sure my PC is staying virus-free?How can I maximize the available resources on my computer?