How often should I run disk cleanup to keep my PC running fast? By YL ComputingSpeed Up PC You should run disk cleanup at least once a month to keep your PC running fast. However, running this utility more frequently will help keep your system running even more efficiently. Related Content:Could installing a faster solid state drive help to improve my PC's speed?What is disk defragmentation, and how does it help speed up my PC?How can I configure Windows to enhance my computer's speed?